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Minimizing Drug Resistant Cases of Gonorrhea through Cost-Effective Treatment Plans

Abstract:


Gonorrhea, caused by the bacterium Neisseria gonorrhoeae, is the second most common bacterial sexually transmitted infection (STI) with a reported 87 million new cases worldwide, according to the World Health Organization (WHO). Gonorrhea has developed resistance to multiple treatment therapies within the past century due to the introduction and misuse of antibiotics. This develops a posing threat of an untreatable infection of drug resistant gonorrhea and a global health crisis. We aim to study a comprehensive treatment strategy with respect to drug resistance in gonorrhea and cost effectiveness. We develop a mathematical model of gonorrhea’s resistance to the two dual treatments recommended by the WHO, ceftriaxone with azithromycin and cefixime with azithromycin. Our cost benefit analysis compares several suggested treatment plans to minimize the emergence of drug resistance. We numerically simulate our model and analyze the reproductive number based on estimated parameters. As a result this study found that the costs are minimized if more than 50 % of individuals are successfully treated.

 

Year: 2019

Authors:

Emily Friedman - Auburn University 

Xin Jin - Shanghai University

Xarissa Levine - Arizona State University

Ixtaccihuatl Obregon - University of the Incarnate Word

Tonantzin Real Rojas - Instituto Tecnologico Autonomo de Mexico

Josean Velazquez-Molina - Arizona State University 

Mugdha Thakur - Arizona State University 

Asma Azizi - Arizona State University 

Baojun Song - Montclair State University 

Christopher Kribs - University of Texas

Aditi Ghosh - University of Wisconsin 

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