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A Mathematical Model of Nosocomial Infection and Antibiotic Resistance: Evaluating the Efficacy of Antimicrobial Cycling Programs and Patient Isolation on Dual Resistance

Hospital-acquired infections caused by antibiotic-resistant bacteria pose a significant threat to public health. Antimicrobial cycling, in which antibiotic classes are alternated over time, has previously been suggested as a strategy for curbing the development of resistance in hospitals. A mathematical model of antimicrobial cycling in a hospital setting is developed in order to analyze the efficacy of such a program, with an emphasis on the emergence and significance of dual resistance. Simulation results compare the effects over time of antimicrobial cycling programs with mixing programs and their ability to reduce antimicrobial resistance. Our model also considers the effects of isolating patients harboring dual-resistant bacteria in the hospital.

Full Title: A mathematical model of nosocomial infection and antibiotic resistance: evaluating the efficacy of antimicrobial cycling programs and patient isolation on dual resistance

Article Number:
MTBI-04-05M

Year:
2007

Authors:
Karen C. Chow, Arizona State University
Xiaohong Wang, Arizona State University
Carlos Castillo-Chavez, Arizona State University

a_mathematical_model_of_nosocomial_infection_and_antibiotic_resistance_evaluating_the_efficacy_of_antimicrobial_cycling._.pdf