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The Effects of Myeloid Cells on Tumor-Immune System Interaction in Different Time Scales

Despite the highly developed mechanism of the immune response, tumor cells often continue to grow uncontrollably. The recognition of tumor cells by specific immune cells is dependent on the balance between immature (ImC) and mature (MmC) myeloid cells in the body, a fact not widely used in tumor growth dynamics models. We propose a mathematical model that incorporates various stages of immune response to tumor growth. Our model includes the dynamics and interactions of tumor cells, natural killer cells, CD8+T cells, immature and mature myeloid cells. The resulting model is given by a five-dimensional non-linear system, which is reduced to a two-dimensional system using time-scale arguments and explored analytically. A discussion on the role of the ratio of immature to mature myeloid cells concludes our presentation.

Article Number:
MTBI-03-01M

Year:
2006

Authors:
Diego Chowell, Facultad de Ciencias
Irina Kareva, University of Maryland
Rosa Torre, Cornell University
Anuj Mubayi, Arizona State University
Fabio Sánchez, Cornell University
Faina Berezovskaya, Howard University

the_effects_of_myeloid_cells_on_tumor-immune_system_interaction_in_different_time_scales_.pdf