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The Effect of Immune Response and Combination Drug Treatment on the Progression of Multi-Strain HIV

Rapidly mutating HIV strains pose difficulties for effective theraphy. By using a mathematical model, we explore the in-host progression of mutating HIV strains considering both the immune response of the host and a combination of antiviral drugs. The first drug inhibits the entry of the HIV virus into CD4+ cells, while the second is a protease inhibitor. We conduct uncertainty and sensitivity analysis of the parameters in the effective reproductive number, R0. Deterministic simulations are performed to illustrate the random behavior of the independent HIV strains on the progression and severity of the disease.

Poster sessions award recipient at the National 2006 AMS convention in San Antonio, TX

Article Number:
MTBI-02-11M

Year:
2005

Authors:
Mat Gluck, University of California, Riverside
Maria Osorio, Univeristy of Arizona
Kelly Smith, Clarion Univeristy
Xiaohong Wang, Arizona State University
Zhilan Feng, Purdue University

the_effect_of_immune_response_and_combination_drug_treatment_on_the_progression_of_multi-strain_hiv_.pdf