Effects of Education, Vaccination and Treatment on HIV Transmission in Homosexuals with Genetic Heterogeneity
Genetic studies report the existence of a mutant allele Δ32 of CCR5 chemokine receptor gene at high allele frequencies (~10 %) in Caucasian populations. The presence of this allele is believed to provide partial or full resistance to HIV. In this study, we look at the impact of education, temporarily effective vaccines and therapies on the dynamics of HIV in homosexually active populations. In our model, it is assumed that some individuals possess an allele (like Δ32 of CCR5) that prevents the successful invasion or replication of HIV. Our model therefore differentiates by genetic and epidemiological status and naturally ignores the reproduction process. Furthermore, HIV infected individuals are classified as rapid, normal or slow progressors. In this complex setting, the basic reproductive number R0 is derived in various situations. The separate or combined effect of therapies, education and vaccines are analyzed. Our results support the conclusions of Shu-Fang Hsu Schmitz that some integrated intervention strategies are far superior to those based on a single approach.
- Poster sessions award recipient at the 2001 National SACNAS Convention in Phoenix, AZ
Sara Del Valle, University of Iowa
Arlene Morales Evangelista, Arizona State University
María Cristina Velasco, Universidad del Valle, Columbia
Project supervisors: Christopher Kribs-Zaleta, University of Texas- Arlington
Carlos Castillo-Chávez, Cornell University