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Macrophage-Activating and Tissue-Damaging Imune Responses to M.tuberculosis

The two principal immune responses against Mycobacterium tuberculosis are the macrophage-activating response (MAR) and the tissue-damaging response (TDR). In the TDR, T-lymphocytes kill those macrophages that permit uncontrolled bacillary growth in their cytoplasm, this mechanism is believed to be responsible for the caseous necrosis in the host's lung tissue. In the MAR, macrophages are activated by T-lymphocytes in order to digest the bacilli as they are engulfed. With the use of a mathematical model we intend to find a proper interplay of both mechanisms to obtain an effective immune response where tissue damage is minimized and still the disease is eradicated.

Article Number:
BU-1429-M

Year:
1997

Authors:
Ariel E. Rodríguez-Herrera, Stanford University
Guarionex Jordán-Salivia, Universidad de Puerto Rico-Río Piedras

macrophage-activating_and_tissue-damaging_imune_responses_to_m.tuberculosis_.pdf